Genome-wide single nucleotide polymorphism analysis identified clonal lineages of Erysipelothrix rhusiopathiae responsible for the recent increased incidence of acute swine erysipelas in Japan

Genome-wide single nucleotide polymorphism analysis identified clonal 1 lineages of Erysipelothrix rhusiopathiae responsible for the recent increased 2 incidence of acute swine erysipelas in Japan 3 4 5 6 Running title: Genome-wide SNP analysis of E. rhusiopathiae strains 7 8 Yohsuke Ogawa , Kazumasa Shiraiwa , Yoshitoshi Ogura , Tadasuke Ooka , 9 Sayaka Nishikawa , Masahiro Eguchi , Tetsuya Hayashi , and Yoshihiro Shimoji a,d,# 10 11 a National Institute of Animal Health, National Agriculture and Food Research 12 Organization (NARO), 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan, 13 b Department of Bacteriology, Faculty of Medicine Sciences, Kyushu University, 3-1-1 14 Maedashi, Higashi-ku, Fukuoka 812-8582, Japan, c Department of Microbiology, 15 Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 16 Sakuragaoka, Kagoshima 891-8544, Japan, d Research Institute for Biomedical 17 Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, 18 Japan 19 20 † These authors contributed equally to this work. 21 # Corresponding author. Mailing address: National Institute of Animal Health, NARO, 22 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan. Phone: 81-29-838-7791. Fax: 23 81-29-838-7790. E-mail: [email protected] 24 AEM Accepted Manuscript Posted Online 17 March 2017 Appl. Environ. Microbiol. doi:10.1128/AEM.00130-17 Copyright © 2017 American Society for Microbiology. All Rights Reserved.